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Further GM-based research should be prioritized for these two HPA axis conditions

Mast cells and KIT as potential therapeutic targets in severe asthma

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Recessive Epidemiology: 4 patients Genetics Mutations: Missense, Duplication, Splice Transcript reduced NDUFAF8 protein Function: Complex I assembly Mitochondrial matrix protein Interacts with NDUFAF5 Clinical Onset age: Prenatal to Childhood Encephalopathy, Acute: May be related to febrile illness Seizures Spasticity Course: Often death Fumarate & Malate Ketone: High in urine Clinical: Varied syndromes COXPD7: Leigh-like syndrome, Optic atrophy & Ophthalmoplegia 113 Mitochondrial translation release factor in rescue (MTRFR