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ACS Appl Mater Interfaces 13:4945349461

doi: 10.3389/fpsyt.2023.1142608 Received 11 January 2023 Accepted 26 January 2023 Published 09 February 2023 Volume 14 - 2023 Edited by iek Hocaolu, Recep Tayyip Erdoan University, Trkiye Reviewed by Mehmet Hamdi rm, Elaz Eitim Ve Aratrma Hastanesi, Trkiye

In our previous attempts with Rosetta-based approaches, designing large structured macrocycles posed significant challenges and required additional disulfide crosslinks to stabilize them 18

Technologies such as transcriptomics and single-cell RNA sequencing are more often being used to identify and understand RNA-level changes by mapping how genes are expressed within individual tumor cells and across different regions of a tumor (see Sidebar 10 )