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doi: 10.1038/nchembio.497 40 DingQ.TianY.WangX.LiP.SuD.WuC.et al

The aetiology is multifactorial with rare monogenic variants

Mechanistic studies have shown that it exerts a protective effect on RF by restoring FAO in renal tissues, reversing defective fatty acid oxidation and intracellular lipid accumulation, inhibiting renal tubular apoptosis, and improving renal function [155]