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Front Pharmacol (2020) 11:584176

In addition to the consensus on the prominent role of cystine starvation in blocking GSH synthesis, the present two studies demonstrated two previously under-appreciated metabolic effects that contribute to the ferroptosis-susceptible state in cancer cells under cystine deprivation conditions: loss of GPX4 protein translation and accumulation of oxidative stress-inducing intracellular glutamate (Fig

Huber M, Wachtlin J (2012) Vitreous levels of proteins implicated in angiogenesis are modulated in patients with retinal or choroidal neovascularization

For sleep, this means the neural circuits responsible for sleep initiation, maintenance, and cycling function more effectively