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Other techniques, such as time-domain near infrared spectroscopy (TD-NIRS), by exploiting the physical relationship between the photon path length (or equivalently the time-of-flight) and the average penetration depth, obtain depth-resolved measurements for the optical properties, but lack information on blood flow 9

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However, precisely identifying this transient window remains challenging due to the difficulty in accurately determining the timing of ovulation, inter-individual differences in follicular dynamics, stochastic variation in hormonal responses, asynchronous follicle development rates, and so on