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583 In addition to the traditionally recognized loss of dopaminergic neurons in the substantia nigra and intracellular alpha-synuclein (-syn) deposition, the brains of PD patients exhibit iron deposition, heightened oxidative stress, and lipid peroxidation damage

[60] supported this hypothesis by showing that lactate stimulates PASMC proliferation in a concentration-dependent manner

Given the pivotal role of TGF signaling in tumor metastasis, we further compared the efficacy of anti-TGF monotherapy with that of anti-TGF plus devimistat combination therapy in a peritoneal metastasis model and a lung metastasis model of GC

doi: 10.3390/molecules17021652 39