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Headaches, body aches, and fatigue typically emerge within 24-72 hours of first dosing, creating what users often describe as a first-dose reaction that generally subsides with continued use

10.1016/j.chemphyslip.2013.10.011 83 PengY.AoM.DongB.JiangY.YuL.ChenZ.et al (2021)

J Exp Med 1992

The proposed HEBA would offer a third method of upwardly adjusting an ACO's historical benchmark, in addition to the existing regional adjustment and prior savings adjustment