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doi: 10.17305/bb.2025.12318 135 GrantMODonnellAMcDermottDFChoueiriTKMotzerRJ

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However, a prolonged half-life of more than 4 h can occur in individuals that either consume an overdose of APAP or that exhibit a clinical history of hepatic injury or chronic liver disease ( As APAP hepatotoxicity is the most common cause of acute liver failure requiring liver transplantation, a better understanding of the molecular events contributing to APAP hepatotoxicity may provide novel opportunities for intervention