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The principal changes are as follows: GHK-Cu for non-injectable routes of administration is being removed from Category 1, and GHK-Cu for injectable routes of administration is separately being removed from Category 2

Patch-testing a new copper-peptide preparation on a small area of skin before wider use is a common community precaution, consistent with how dermatology approaches suspected contact allergens

These studies suggest that low circulating IGF-I bioactivity and/or abnormalities of IGF-I signaling in elderly subjects, may play an important role in age-related sarcopenia and osteopenia, where the substitutive IGF-I treatment may be a suitable therapeutic strategy, although this apparent IGF-I resistance may dampen this aim