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Jhunjhunwala MBBS, D.ORTH, MS ORTH Fellowships: FCPS ORTH, FICS Senior Ortho Consultant, Post Graduate Institute of Medical Sciences, Bombay Hospital, Mumbai (India) Vitamin B12 is an essential cofactor which is required for normal functioning of various processes related to DNA and cell metabolism

One of its main roles is to act as a cofactor (a helper molecule) in the biochemical reactions continuously performed by enzymes

Gastrointestinal effects lead: nausea, diarrhea, constipation, and vomiting, dose-dependent and clustered during escalation, mostly mild. Tirzepatide also produces a modest chronic heart-rate rise with a larger escalation-phase peak. Oral-contraceptive absorption can fall after starting and after each increase, so use backup or non-oral contraception for 4 weeks each time. What is known about concurrent metformin and tirzepatide use

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity