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Chronic ROS exposure thus creates a vicious cycle: Protein oxidation impairs proteasomal degradation, resulting in further accumulation of damaged proteins that exacerbate oxidative stress [56]

185,186,187 In contrast to the positive effect of NAD + on DNA repair, NADP + suppresses the ADP-ribosylation-mediated DNA damage repair via functioning as an endogenous inhibitor of PARPs