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The amyloid-related pathology can be associated with two deleterious mechanisms: (i) the inability of the amyloid-forming protein to perform its native function, termed as loss of function mechanism and (ii) the amyloid deposit itself is to the cellular metabolism, referred as toxic gain of function (Winklhofer et al., 2008)

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Methylcobalamin is generally considered the fastest acting because it is already in an active form and does not require conversion