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Generating Human Ipsc-Derived Astrocytes With Chemically Defined Medium for In Vitro Disease Modeling

3f and 6f), suggesting that increased oxygen availability, which may activate the TCA cycle to produce 2-OG, was not the main factor contributing to enhanced glutamate production in the 90 plate

Antitumor The TME exhibits distinctive characteristics, including hypoxia, acidic pH, and elevated levels of reduced glutathione (GSH) and H 2 O 2 , which collectively create a conducive environment for tumor proliferation, invasion, migration, adhesion, and neovascularization