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Through conjugation with the DOTA chelator and subsequent radiolabeling with the positron-emitting radionuclide copper-64 ( 64 Cu), daratumumab has been successfully developed as a molecular probe targeting CD38-expressing MM cells [102]

Warning 3

This approach bypasses the bodys digestive system by injecting the materials directly into cells for faster absorption

The story of how this barrier was ultimately overcome, first partially through formulation technology and then completely through molecular innovation, is a story of iterative failure, creative problem-solving, and the eventual triumph of small-molecule chemistry over the constraints of peptide biology