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While the formation of 5-(3,4-dihydroxyphenyl)--valerolactone from (+)-catechin by intestinal bacteria has already been described by Das ( Eggerthelia lenta and Adlercreutzia equolifaciens species, followed by activities of Flavonifractor plautii strains ( 2 , with monomers being linked via a single interflavan bond, are more readily cleaved compared to A-type procyanidins with two interflavan bonds ( After intake of Pycnogenol , the microbial metabolites 5-(3,4-dihydroxyphenyl)--valerolactone (previously also named -(3,4-dihydroxyphenyl)--valerolactone or M1) and 5-(3- methoxy-,4-hydroxyphenyl)--valerolactone (previously also called -(3- methoxy-,4-hydroxyphenyl)--valerolactone or M2) were identified in urine samples of a volunteer as phase II conjugates (

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Drugs Today (Barc) 2005;41(7):453-9

It is essential to consult with your healthcare provider before adding these to your routine if you are taking any prescription medications