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It has been reported that iron inhibits Nrf2 promoting -syn aggregation, which ultimately exacerbates ferroptosis (Gan and Johnson, 2014)

Nevertheless, as devastating as COVID-19 is, it may serve as an impetus for the scientific community, funding bodies, and stakeholders to commit more focused efforts toward development of platform technologies that bolster the preparedness for future pandemics

4.3 Blood-retinal barrier BRB serves to sequester retinal antigens within the eye, thereby preventing their recognition by the peripheral immune system and inhibiting the entry of unactivated T cells into the retina, thus averting retinal inflammation (98, 102)

Even though the exact structure of the mPTP, as well as its assembly kinetics, is still unknown, interesting findings suggested that dissociation of F 1 F O ATP synthase dimers 45 and the c subunit pore-forming part 46 have an important role in mitochondrial permeability transition (mPT) and constitute a valid therapeutic approach in pathologies subjected to widespread cell death 47,48