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Mutated cases were heterozygous, with a low prevalence (6/243, 2.46% frequency), co-occurred with gastric CIMP and MSI (Fishers exact test, P = 0.001), and exhibited promoter hypermethylation ( -value range 0.590.79), suggesting that genetic mutations are much less frequent than epimutations at the CBS locus and may or may not represent passenger events owing to MSI

Similarly to GPX4, GCLC, a key enzyme for glutamine-derived GSH biosynthesis, was ectopically expressed in OT-1 CD8 + T cells through a PiggyBac transposon system (Figure 2, N and O) and treated ex vivo with or without A2ARi

Skewed Distribution of Hypothyroidism in the Coastal Communities of Newfoundland, Canada

doi: 10.1111/jpn.13759