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This lack of effect on ACTH and cortisol plasma levels was evident even at doses more than 200-fold higher than the ED50 for GH release

The official reason given is safety, even though these peptides have been used safely for years and are produced by reputable compounding pharmacies

Constancia M, Hemberger M, Hughes J, Dean W, Ferguson-Smith A, Fundele R, Stewart F, Kelsey G, Fowden A, Sibley C, Reik W: Placental-specific IGF-II is a major modulator of placental and fetal growth

Also, the percentage of mean change was calculated for each subject from baseline to week 5 and from baseline to week 10, and then MannWhitney test was employed to determine the difference in the mean of the percentage of mean difference between the two groups