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Description

Enhanced antibody half-life improves in vivo activity

J Pharm Innov 18(4):20752082

Timestamp, hh:mm:ss

In adult mice, HIF1 deletion in the dorsal forebrain, including in NPCs, impairs neurogenesis by reducing NPC proliferation and impeding differentiation (Mazumdar et al , 2010) but all previously used HIF1 targeting strategies could not exclude effects on other niche cells (Iyer et al , 1998