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Transformation of Lipophilic Compounds : Both phases aim to increase the water solubility and polarity of lipophilic compounds

These results obtained both in vitro and in vivo suggest the clinical value of ALA for the therapy of cisplatin-induced ototoxicity [92]

10.1242/jcs.093849 58 KaganV.JiangJ.HuangZ.TyurinaY.DesbourdesC.Cottet-RousselleC.et al (2016)

261, 262 Although high rates of efficacy were reported (47 to 64%), given the extremely small combined sample size of fewer than 30 patients, the relatively serious AEs (e.g., new diabetes onset, exacerbation of existing diabetes, pneumonia with septic shock, increased blood pressure), and the known risks of systemic long-term glucorticoid use, risks/burdens clearly outweigh benefits and the Panel recommends that this therapy not be used long-term