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6.3 Epigenetic Reprogramming Strategy Given NNMTs role in the epigenetic architecture of tumor stroma, targeting it may help overcome therapy resistancespecifically in cancers where tumor angiogenesis and fibrosis are driven by NNMTexpressing fibroblasts

PDI speeds this shuffling by several thousand fold

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The team worked around this by adopting a physical organic chemistry approach to precisely tune the reactivity to distinguish between normal and pathological states