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[2] An important caveat applies to all of this work: these studies measure DSIP-like immunoreactivity (DSIP-LI) using antisera, which detects material that cross-reacts with the antibody

Sanin DE, Matsushita M, Klein Geltink RI, Grzes KM, van Teijlingen Bakker N, Corrado M, Kabat AM, Buck MD, Qiu J, Lawless SJ, et al

Moreover, another clinical study demonstrated that epithalmine improved lipid metabolism and arterial blood pressure in women with ischemic heart disease and hypertension [12]

A scientific review published in the National Library of Medicine in 2022 found that nose-to-brain delivery of therapeutic peptides is a non-invasive and fast-acting method that can effectively bypass the blood-brain barrier while minimizing systemic exposure