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Mikus D, Sikiric P, Seiwerth S, et al

We determined the effect of the compounds to promote oligodendrogenesis at the lesion site by combinatory immunodetection of Olig2, CC1, and Olig1, allowing to distinguish OPCs (Olig2 high /CC1 - /Olig1 nuclear-cyto cells) and three stages in OL differentiation 53,84 : immature OL (iOL) 1 (iOL1, Olig2 high /CC1 high /Olig1 - cells), iOL2 (Olig2 high /CC1 high /Olig1 high-cyto cells), and mOL (Olig2 low /CC1 low /Olig1 low cells