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This disconnect occurs because folate transport across the blood-brain barrier is impaired

Front Cardiovas Med

In contrast, in in vivo assay, xCT-KO pancreatic ductal adenocarcinoma (PDAC) cells injected subcutaneously managed to form a tumor, although with a short delay

Moreover, proteomics screening revealed that monocarboxylate transporter 1 (MCT1, protein for the SLC16A1 gene) and lactate dehydrogenase B (LDHB), responsible for lactate uptake and oxidation, respectively, were among the top three significantly upregulated proteins in AR cells (Fig