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However, the direct oxidation of Cys and, to a lesser extent, methionine residues with H 2 O 2 can give rise to reversible modifications, such as sulfenic acid or disulfides or as methionine sulfoxides, respectively, which can be reduced by cellular activities

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Given that diverse extracellular cues can provoke neutrophils to form NETs, our findings suggest that ROS and Ca 2+ act as two principal intracellular mediators of this process