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In the case of GSAO, a reversible renal toxicity described in preclinical studies at the maximal tolerated dose was not observed in human during clinical Phase I (Horsley et al., 2013)

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Moreover, anti-MMP-9 antibody treatment in C3HeB/FeJ mice led to the development of hypoxic TB granulomas and cavitary lesions, resulting in a lower relapse rate, although this was not significantly different [138]