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The frequency of lactic acidosis was 4064 per 100,000 patients per year and probably related to renal insufficiency similar to metformin therapy 64

Xia, M., Ma, J., Sun, S., Li, W

PF significantly shortened the 5-min swimming immobility time of the rats in the FST model and increased the 5-min moving distance in the open-field trials, showing an antidepressant effect similar to fluoxetine