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444 In cases of extensive necrosis involving the retrocolic and/or mesenteric spaces where complete necrosectomy cannot be achieved in a single procedure, open packing or staged laparotomy may be employed as a damage control strategy

Furthermore, some disturbance in these organelles activates signaling pathways that alter cardiac ion channels function or expression, involved in the generation of an action potential that promotes arrhythmogenesis (Tse et al., 2016)

The cDNA samples were amplified using a SYBR Green fluorescent PCR kit (Vazyme Biotech Co., Ltd.) on a fluorescence qPCR instrument (QuantStudio DX