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For example, repeated social defeat stress resulted in increased oxidative stress in the hippocampus but not the amygdala and cortex in rats (Patki et al., 2013)

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For instance, animal models for SZ that show both high oxidative stress levels and PFC hypomyelination (such as the APO-SUS rats, and the rodent prenatal infection and hypoxia models) may be treated with antioxidants from a young age onwards to assess whether lowering oxidative stress can (partially) rescue myelination deficits in the PFC, together with PFC-dependent cognitive functioning, and evaluate the width of the therapeutic window