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It is is caracteristized by a prolonged exhaustion state, uneasily relieved by rest and often exacerbated by physical or intellectual effort and emotions

Other than that, glucotoxicity-activated ERS can mediate neuronal apoptosis and nerve tissue damage, thereby promoting DPN progression (104)

Management and therapeutic education for patients and allergen avoidance Daily management of patients with allergic diseases and educational intervention plays an essential role in managing difficult-to-treat allergic cases