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Minocycline is a tetracycline antibiotic that showed to increase neuronal survival, as well as being able to reduce proinflammatory cytokines production and modulating glutamate and monoaminergic pathways, which explains its anti-inflammatory and neuroprotective activity [316]

To mitigate mutagenesis, carcinogenesis, and some other forms of toxicity, transcription organization and antioxidant responses are triggered within the body (Butt et al., 2009)

It has been suggested that an inadequate dietary intake of these trace minerals may compromise the effectiveness of these antioxidant defense mechanisms

88 The histone demethylase KDM3B prevents ferroptosis in HT1080 cells by upregulating SLC7A11 in an ATF4-dependent fashion