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Carter AJ, OConnor WT, Carter MJ, Ungerstedt U

43 In a phase 3 trial including patients with obesity (excluding T2DM), the highest dose group achieved a mean weight reduction of 11.2% by week 72

doi: 10.1210/jc.2006-1631 160 JohnsenSPHundborgHHSrensenHTOrskovHTjnnelandAOvervadKet al

Technological limitations also persist, as non-invasive methods for assessing oxidative stress in the human brain during sleep are still under development, restricting real-time, in vivo observations