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Important Note on the Evidence Base Important note on the evidence base: The preclinical AOD-9604 literature in obese mouse and Zucker rat models is consistent and reproducible

Cortex 23 , 23222336, (2013)

Indeed, in vitro studies showed that cells expressing the sst 5 TMD2 mainly respond to cortistatin, whereas those expressing sst 5 TMD4 were exclusively activated by somatostatin and those bearing the sst 5 TMD1 responded to both ligands (Cordoba-Chacon et al., 5 TMD4, while somatostatin activates the sst 5 TMD5 (Duran-Prado et al., Somatostatin in the brain exerts a wide variety of physiological functions besides the initially described inhibitory effect on growth hormone release