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Moreover, strong down-regulation of the gene encoding the plasma membrane calcium-transporting ATPase ( PMCA ) occurs in bovine Peyer' patches early in infection (Santos et al., 2002), thus increasing the cellular calcium level which affects various metabolic processes, including enhanced mitochondrial ATP synthesis (Jouaville et al., 1999)

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Genetic interactions correlated with prognostic genes, and TIDE and ESTIMATE analyses suggested higher tumor immune evasion probability in the high-risk group, providing a rationale for immunotherapy

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