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neuropathy), effective replacement therapy should lead to a normal full blood count and B12 level after 8 weeks of treatment, while improvement in neurological symptoms begins very quickly within one week of initiation of therapy but can take up to 3 months to resolve (Carmel, 2008)

Murine studies show no acute toxicity at doses up to 100 mg/kg, and the Nature Metabolism paper reported no adverse metabolic effects during the 11-week treatment period

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However, the effects are typically shorter-lived than B12 shots, with most people scheduling treatments every few weeks to maintain optimal vitamin levels