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From an implementation standpoint, the standardized liquid formulation enables rapid local absorption with minimal systemic exposure and ensures uniform mucosal coverage, consistent dosing, and prolonged mucosal contact, features likely to reduce the formulation heterogeneity that has hampered prior topical studies and to enhance adherence 21

TRO is a ligand of peroxisome proliferator-activated receptor (PPAR), which activates GPX3 as a direct upstream factor [67]

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Consistent with this finding, multiple RP/MRD cell lines had higher ATP levels than their starting cells (Figure 4C)