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The severity and duration of deficiency are primary determinantspatients with mild, recently developed deficiency typically respond more rapidly than those with longstanding, severe depletion

It involves weighing several critical factors, each with its own ripple effect on your research project: Research Goals and Endpoints: Are you looking for a sustained, moderate effect over a long period, or a rapid, potent peak concentration

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[1] [2] However, longstanding neurological complications, such as peripheral neuropathy or cognitive changes, may require three to six months of consistent treatment before significant improvement occurs, and some damage may be irreversible if treatment is delayed