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Additionally, decreased serum testosterone levels due to diabetes can negatively affect vascular endothelial function, further contributing to ED ( 2.2 Testicular glucose metabolism and infertility Hyperglycemia in diabetes alters testicular glucose metabolism

However, the approach was also used for the improvement of brain delivery of therapeutic agents with extracellular targets including a neurotransmitter dopamine, competitive antagonist of the glycine site of the NMDA receptor 7-chlorokynurenic acid, serotonin-norepinephrine reuptake inhibitor venlafaxine and inhibitor of the GABA transporter nipecotic acid (Table II, III)