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Diarrhea, nausea, and vomiting occurred more frequently during dose escalation and declined gradually over time

CBT-I (Cognitive Behavioral Therapy for Insomnia) Mechanism: Behavioral/psychological intervention with the strongest long-term evidence for chronic insomnia

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That, however, disregards the fact that alternative enzymatic pathways exist that may allow the synthesis of the smaller, later angiotensin peptides despite blockade of enzymes like ACE [6], and that the brain possesses a complete renin-angiotensin system that may be affected differently by therapeutic agents with limited ability to cross the blood brain barrier than the peripheral renin-angiotensin system [7]