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Several parameters related to CXCL16 levels in metastatic bone marrow of advanced PCa patients may predict bone metastasis

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In type 1 diabetes, where IGF-I and IGFBP-3 levels are decreased[302], substitutive rhIGF-I/IGFBP-3 therapy enhances protein[303] and glucose metabolism by controlling both endogenous glucose output and peripheral glucose uptake[304]

Ethics statement The animal study was approved by the experimental protocol was approved by the Institutional Animal Care and Use Committee of Jining Medical University (Approval No