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Thresholds for defining excessive B12 supplementation were based on the fact that an oral cyanocobalamine supplementation with 1000 g/week (or injectable supplements of 1000 g/month) is sufficient for most cases of B12 deficiency, except for pernicious anemia and some rare causes with limited absorption or trafficking of cobalamin [25]

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No IGF-1 elevation: HGH increases insulin-like growth factor 1 (IGF-1), which promotes growth of all tissues - including potentially problematic growth