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However, to our knowledge, only one study has assessed the effect of TNF- on GPX3 expression and shown that, in adipose tissue, GPX3 expression is markedly decreased by TNF-, in agreement with our observation 55

However, clinical recommendations from the European League Against Rheumatism (EULAR) and other organizations point to a multidisciplinary point of view of FM and its treatment ( In this context, this study is focused on biomarker discovery for FM in plasma and feces from 199 FM patients and 43 women as a control group, aiming to combine the analysis of both samples in a diagnostic panel for clinical practice