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Astrocytic Kir4.1 potassium channels as a novel therapeutic target for epilepsy and mood disorders

The survival curve was drawn based on the number of days each mouse survived in the control group, the SLC25A11-knockdown group, and the SLC25A11-knockdown group combined with Fer-1, respectively

62,99,100 Together, these reports provide strong evidence that after an APAP overdose, in vivo and in isolated hepatocytes in culture, ferrous iron can be released from lysosomes and then taken up into mitochondria via the MCFU, where it contributes to MPTP opening and cell death (Fig