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People may seek skin whitening for various reasons, including correcting hyperpigmentation, reducing the appearance of dark spots or blemishes, or simply for cosmetic purposes

Importantly, the relative activities of these regulons were consistently deregulated across most PFG and PEN clusters (Fig

As provided herein, mutations can be introduced which result in conformational changes from an FXa form to a zymogen type form, which when in a fully active form in the presence of the fVa cofactor, exhibits catalytic activity against prothrombin

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