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Furthermore, we emphasize that oral and topical antibiotics alone are of limited effectiveness and should be avoided

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More importantly, the PGI-R directly assesses the degree of improvement, whereas the other assessment tools only indirectly assess the degree of improvement by calculating a small difference between two large numbers (initial and final), which leads to a greater uncertainty in the degree of improvement

The primary mode of NRF2 regulation is at the protein level, with three primary E3 ubiquitin ligase complexes mediating the ubiquitylation and subsequent degradation of NRF2 by the 26S proteasome: 1 ) KEAP1-CUL3-RBX1, 2 ) HRD1 (also known as synoviolin), and 3 ) SCF/-TRCP