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Hence, their mechanisms and clinical applications differ

This, in turn, further disrupts GBA activity by hindering its trafficking from the endoplasmic reticulum to the Golgi to lysosomes, ultimately contributing to neurodegeneration [117]

Furthermore, although CsA is a well-known inhibitor of the mitochondrial permeability transition pore through blocking cyclophilin D [54], examination of its immediate effects on mitochondrial function showed only marginal changes (Additional file 1: Fig