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Although TR/GR-null livers generate some of their cysteine through the serine transsulfuration pathway, we here show that most cysteine in TR/GR-null livers comes from a pathway in which pyridoxal-phosphate-dependent cleavage of a carbonsulfur bond in cystine generates cysteine persulfide, which decomposes nonenzymatically into cysteine

Vitamin B12 therefore has a central, hormone-like effect in the nervous system

The usual intramuscular dose is between 1000 mcg and 2500 mcg per shot