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Transplantation 83 , 13711379, doi: 10.1097/01.tp.0000264200.38926.70 (2007)

Chelation therapy involves the use of agents to remove heavy metals from the body

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Consequently, intracellular zinc homeostasis alterations regulate downstream molecular objectives, in addition to protein kinase C (PKC), ERK1/2 activation leading to neuronal cell death, cAMP-dependent protein kinase (PKA), Ca/calmodulin-dependent protein kinase II (CaMKII), phosphodiesterases (PDEs), protein tyrosine phosphatases (PTPs), and transcription factors, such as NF-B