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These results suggest that MAPL contributes to excessive fission, mitochondrial dysfunction and NPC death by promoting the recruitment of SUMOylated Drp1 to mitochondria

R.SchoneveldE.LucchiniM.ThakurS.AndersT.et al (2023)

This structural deterioration increases the mechanical stress on the annulus fibrosus, eventually causing the nucleus pulposus to herniate through annular fissures, thereby initiating LDH (110)