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The lipotropic agents (methionine, inositol, choline) are pH-sensitive and oxidise rapidly once exposed to air and moisture, which is why the 72-hour window exists rather than the 28-day stability window you'd see with straight methylcobalamin

It suggests either multiple pathways activated at different dose ranges or extreme potency with receptor saturation at low doses

A serum B12 test measures the total B12 in serum and this total includes both the active and inactive portions